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Product Information:

CFM-2

CFM-2 is a potent and selective non-competitive AMPAR antagonist[1]. CFM-2 possesses anticonvulsant activity in various models of seizures[2].

Cat. No.: EX-A14447    Purity: >98%
Chemical
Chemical structure of CFM-2


For research only, Do not use for Human!

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CAS No.178616-26-7
Purity>98%
FormulaC17H17N3O3
Mol Weight311.3352
ColorLight yellow to khaki
StateSolid
Solubilitysoluble in DMSO
Shelf Life>3 years if stored properly
StoragePowder -20℃, 3 years; 4℃, 2 years; In solvent -20℃, 1 year;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. De Sarro G, et al. Effects of some AMPA receptor antagonists on the development of tolerance in epilepsy-prone rats and in pentylenetetrazole kindled rats. Eur J Pharmacol. 1999 Mar 5;368(2-3):149-59.

[2]. Rizzo M, et al. Determination of new 2,3-benzodiazepines in rat plasma using high-performance liquid chromatography with ultraviolet detection. J Chromatogr B Biomed Sci Appl. 1999 Aug 20;731(2):207-15.

[3]. Stepulak A, et al. AMPA antagonists inhibit the extracellular signal regulated kinase pathway and suppress lung cancer growth. Cancer Biol Ther. 2007 Dec;6(12):1908-15.

[4]. Park JS, et al. Role of spinal cord alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors in complete Freund's adjuvant-induced inflammatory pain. Mol Pain. 2008 Dec 30;4:67.

CoACoA of CFM-2
Smiles:COC1=C(C=C2C(=C1)CC(=O)NN=C2C3=CC=C(C=C3)N)OC

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