background


Product Information:

CFI-402257 hydrochloride

CFI-402257 hydrochloride is a highly selective and orally bioavailable TTK/Mps1 inhibitor with an IC50 of 1.7 nM for TTK in vitro. CFI-402257 hydrochloride has anti-cancer activity .

Cat. No.: EX-A2577A    Purity: >98%
Chemical
Chemical structure of CFI-402257 hydrochloride


For research only, Do not use for Human!

SizeUnit Price (US$)StockQuantityOrder
1gget quoteInquire


SynonymsLuvixasertib hydrochloride
Synonyms 2CFI-402257 hydrochloride
CAS No.1610677-37-6
Purity>98%
FormulaC28H31ClN6O3
Mol Weight535.037
ColorLight yellow to yellow
StateSolid
SolubilitySoluble in DMSO
Shelf Life>3 years if stored properly
StoragePowder 4°C, sealed storage, away from moisture and light; In solvent -20°C, 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Liu Y, et al. Discovery of Pyrazolo[1,5-a]pyrimidine TTK Inhibitors: CFI-402257 is a Potent, Selective, Bioavailable Anticancer Agent. ACS Med Chem Lett. 2016 May 6;7(7):671-5.

[2]. Mason JM, et al. Functional characterization of CFI-402257, a potent and selective Mps1/TTK kinase inhibitor, for the treatment of cancer. Proc Natl Acad Sci U S A. 2017 Mar 21;114(12):3127-3132.

CoACoA of CFI-402257 hydrochloride
Smiles:CC1=CC(C2=C3N=C(OC4=CN=CC=C4)C=C(NC[C@@H]5C[C@@](O)(C)C5)N3N=C2)=CC=C1C(NC6CC6)=O.Cl

KEYWORDS: buy CFI-402257 hydrochloride | CFI-402257 hydrochloride supplier | purchase | cost | manufacturer | order | distributor | buy 1610677-37-6 | 1610677-37-6 supplier