CDK4-IN-1

CDK4 inhibitor is a selective inhibitor of cyclin-dependent kinase 4 with IC50 value of 10 nM. Cyclin-dependent kinase 4 (CDK4) is a Ser/Thr protein kinase and is a member of the cyclin-dependent kinase family. CDK4 plays an important role in the G1-S phase.


Cat. No.: EX-A1051	Purity: >98%

	Chemical structure of CDK4-IN-1

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
100mg	1250	In-stock
250mg	1965	In-stock
5g	9750	6 weeks

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Synonyms	CDK 4/6 Inhibitor
Synonyms 2	LEE011 analog
CAS No.	1256963-02-6
Purity	>98%
Formula	C22H29ClN8
Mol Weight	440.972
State	solid powder
Solubility	DMSO > 50 mg/mL
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Cho YS, Borland M, Brain C, et al. 4-(Pyrazol-4-yl)-pyrimidines as selective inhibitors of cyclin-dependent kinase 4/6. J Med Chem, 2010, 53(22): 7938-7957.
CoA	CoA of CDK4-IN-1

Smiles:	CC(C)C1=NNC(Cl)=C1C1=NC(NC2=NC=C(C=C2)N2CCC(CC2)N(C)C)=NC=C1


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