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Product Information:

CDK12-IN-6

CDK12-IN-6, a pyrazolotriazine, is a potent CDK12 inhibitor with an IC50 of 1.19 μM at high ATP (2 mM). CDK12-IN-6 has no effect on CDK2/Cyclin E (IC50>20 μM) and CDK9/Cyclin T1 (IC50>20 μM) at high ATP (2 mM) (WO2021116178A1).

Cat. No.: EX-A13852    Purity: >98%
Chemical
Chemical structure of CDK12-IN-6


For research only, Do not use for Human!

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CAS No.2651196-71-1
Purity>98%
FormulaC20H21F2N9
Mol Weight425.4378
ColorWhite to off-white
StateSolid
SolubilityDMSO : 100 mg/mL
Shelf Life>3 years if stored properly
StoragePowder -20°C, 3 years, 4°C, 2 years; In solvent -20°C, 1 month.
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Kai Thede, et al. Pyrazolotriazines. WO2021116178A1.

CoACoA of CDK12-IN-6
Smiles:FC1=C2C(N=C(CNC3=NC(N4CCNCC4)=NC5=C(C6CC6)C=NN53)N2)=CC=C1F

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