CDK-IN-9

CDK-IN-9 (compound 24) is a potent CDK inhibitor, also as a molecular glue inducing an interaction between CDK12 and DDB1, with an IC50 values of 4 nM for CDK2/E. CDK-IN-9 leads to polyubiquitination of cyclin K and its subsequent degradation. CDK-IN-9 induce apoptosis through dephosphorylation of retinoblastoma protein and RNA polymerase II .


Cat. No.: EX-A10025	Purity: >98%

	Chemical structure of CDK-IN-9

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
5mg	498	In-stock
10mg	795	In-stock
25mg	1580	In-stock
50mg	2500	In-stock
100mg	3980	In-stock
250mg	8100	In-stock

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CAS No.	3031561-92-6
Purity	>98%
Formula	C21H24N8S
Mol Weight	420.534
State	solid
Solubility	soluble in DMSO
Shelf Life	>3 years if stored properly
Storage	Powder 4℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Jorda R, et al. 3,5,7-Substituted Pyrazolo[4,3-d]Pyrimidine Inhibitors of Cyclin-Dependent Kinases and Cyclin K Degraders. J Med Chem. 2022 Jul 14;65(13):8881-8896.
CoA	CoA of CDK-IN-9

Smiles:	NCCSC1=NC2=C(NN=C2C(NCC3=CC=C(C=C3)N4C=CC=N4)=N1)C5CCC5


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