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Product Information:

CCT241533 hydrochloride

CCT241533 hydrochloride is a potent and selective CHK2 inhibitor with an IC50 of 3 nM and a Ki of 1.16 nM.

Cat. No.: EX-A10505    Purity: >98%
Chemical
Chemical structure of CCT241533 hydrochloride


For research only, Do not use for Human!

SizeUnit Price (US$)StockQuantityOrder
250mg928In-stock
500mg1654In-stock
1g2776In-stock
2g3996In-stock
5gget quote


CAS No.1431697-96-9
Purity>98%
FormulaC23H28ClFN4O4
Mol Weight478.944
Colorwhite to light yellow
Statesolid
Solubilitysoluble in DMSO/H2O
Shelf Life>3 years if stored properly
Storage4℃,sealed storage, away from moisture, 2 years; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Anderson VE, et al. CCT241533 is a potent and selective inhibitor of CHK2 that potentiates the cytotoxicity of PARP inhibitors. Cancer Res. 2011 Jan 15;71(2):463-72.

[2]. Caldwell JJ, et al. Structure-based design of potent and selective 2-(quinazolin-2-yl)phenol inhibitors of checkpoint kinase 2. J Med Chem. 2011 Jan 27;54(2):580-90.

CoACoA of CCT241533 hydrochloride
Smiles:[H]Cl.COC1=C(OC)C=C(C(N[C@H]2[C@H](C(C)(C)O)CNC2)=NC(C3=C(O)C=CC(F)=C3)=N4)C4=C1

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