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Product Information:

CCR2-RA-[R]

CCR2-RA-[R] is an allosteric antagonist of the C-C chemokine receptor type 2 (CCR2) with an IC50 of 103 nM.

Cat. No.: EX-A9358    Purity: >98%
Chemical
Chemical structure of CCR2-RA-[R]


For research only, Do not use for Human!

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CAS No.512177-83-2
Purity>98%
FormulaC18H19ClFNO3
Mol Weight351.8
ColorWhite to yellow
StateSolid
SolubilitySoluble in DMSO
Shelf Life>3 years if stored properly
StoragePowder -20℃ 3 years, 4℃ 2 years; In solvent -20℃ 1 year;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Zweemer AJ, et al. Multiple binding sites for small-molecule antagonists at the CC chemokine receptor 2. Mol Pharmacol. 2013 Oct;84(4):551-61.

[2]. Zweemer AJ, et al. Discovery and mapping of an intracellular antagonist binding site at the chemokine receptor CCR2. Mol Pharmacol. 2014 Oct;86(4):358-68.

[3]. Zheng Y, et al. Structure of CC chemokine receptor 2 with orthosteric and allosteric antagonists. Nature. 2016 Dec 15;540(7633):458-461.

CoACoA of CCR2-RA-[R]
Smiles:CC(=O)C1=C(O)C(=O)N([C@@H]1C1CCCCC1)C1=CC=C(Cl)C=C1F

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