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Product Information:

CC-401

CC-401 is a potent inhibitor of all three forms of JNK with Ki of 25 to 50 nM.

Cat. No.: EX-A3583A    Purity: >98%
Chemical
Chemical structure of CC-401


For research only, Do not use for Human!

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CAS No.395104-30-0
Purity>98%
FormulaC22H24N6O
Mol Weight388.4656
ColorWhite to off-white
Statesolid
SolubilityDMSO : 40 mg/mL
Shelf Life>3 years if stored properly
StoragePowder 4°C, sealed storage, away from moisture and light; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Ma FY, et al. A pathogenic role for c-Jun amino-terminal kinase signaling in renal fibrosis and tubular cell apoptosis. J Am Soc Nephrol. 2007 Feb;18(2):472-84.

[2]. Vasilevskaya IA, et al. Inhibition of JNK Sensitizes Hypoxic Colon Cancer Cells to DNA-Damaging Agents. Clin Cancer Res. 2015 Sep 15;21(18):4143-52.

[3]. Ma FY, et al. Blockade of the c-Jun amino terminal kinase prevents crescent formation and halts established anti-GBM glomerulonephritis in the rat. Lab Invest. 2009 Apr;89(4):470-84.

CoACoA of CC-401
Smiles:C1(C2=CC=CC(OCCN3CCCCC3)=C2)=NNC4=C1C=C(C=C4)C5=NC=NN5

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