CC-122

Avadomide (CC 122) is an orally active cereblon modulator. Avadomide modulates cereblon E3 ligase activity and induces apoptosis of diffuse large B-cell lymphoma (DLBCL) cell lines. Avadomide exhibits potent antitumor and immunomodulatory activities.


Cat. No.: EX-A1191	Purity: >98%

	Chemical structure of CC-122

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
500mg	491	in_stock
1g	798	in_stock
2g	1256	in_stock
3g	1520	in_stock
5g	2024	in_stock
10g	3158	in_stock

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Synonyms	Avadomide
CAS No.	1015474-32-4
Purity	>98%
Formula	C14H14N4O3
Mol Weight	286.286
State	solid powder
Solubility	Soluble in DMSO
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Rasco DW, et al. A First-in-Human Study of Novel Cereblon Modulator Avadomide (CC-122) in Advanced Malignancies. Clin Cancer Res. 2019 Jan 1;25(1):90-98. [2]. Hagner, P.R.et al.CC-122, a pleiotropic pathway modifier, mimics an IFN response and has antitumor activity in DLBCL.Blood.Aug 6;126(6):779-89.
CoA	CoA of CC-122

Smiles:	CC1=NC2=C(C(N)=CC=C2)C(=O)N1C1CCC(=O)NC1=O


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