CBR-5884

CBR-5884 is an active, selective inhibitor of phosphoglycerate dehydrogenase (PHGDH) with an IC50 of 33 μM. CBR-5884 inhibits de novo serine synthesis in cancer cells and is selectively toxic to cancer cell lines with high serine biosynthetic activity.


Cat. No.: EX-A4800	Purity: 98+%

	Chemical structure of CBR-5884

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
100mg	365	In-stock
250mg	585	In-stock
500mg	785	In-stock
1g	1185	In-stock
5g	3555	In-stock
10g	5332	In-stock

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CAS No.	681159-27-3
Purity	98+%
Formula	C14H12N2O4S2
Mol Weight	336.386
State	solid powder
Solubility	Soluble in DMSO
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Edouard Mullarky et al. Identification of a small molecule inhibitor of 3-phosphoglycerate dehydrogenase to target serine biosynthesis in cancers Proc Natl Acad Sci U S A, 2016 Feb 16, 113(7):1778-83.
CoA	CoA of CBR-5884

Smiles:	O=C(C1=CC=CO1)NC2=C(SC#N)C(C)=C(C(OCC)=O)S2


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