CBPD-268

CBPD-268 is a potent and orally active CBP/p300 PROTAC degrader with an DC50 value of ≤ 0.03 nM. CBPD-268 induces CBP/p300 degradation and inhibits cell growth. CBPD-268 shows antitumor activity. CBPD-268 has the potential for the research of AR-positive prostate cancer (Structure Note: Red, Androgen receptor degrader ; Blue, CBP/p300 ligand; Black, Linker) .


Cat. No.: EX-A8900	Purity: >98%

	Chemical structure of CBPD-268

For research only, Do not use for Human!

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CAS No.	2832961-58-5
Purity	>98%
Formula	C44H47F2N9O5
Mol Weight	819.8981
Color	White to light yellow
State	Solid
Solubility	Soluble in DMSO
Shelf Life	>3 years if stored properly
Storage	Powder -20℃ 3 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Chen Z, et al. Discovery of CBPD-268 as an Exceptionally Potent and Orally Efficacious CBP/p300 PROTAC Degrader Capable of Achieving Tumor Regression. J Med Chem. 2024 Apr 11;67(7):5275-5304.
CoA	CoA of CBPD-268


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