CB039

CB039 is a selective a molecular glue degrader that targets RBM39 (RNA-binding protein 39). CB039 promotes the formation of a ternary complex between RBM39 and the E3 ubiquitin ligase CUL4-DCAF15, leading to proteasomal degradation of RBM39. CB039 is promising for research of cancers with RBM39 dependency, such as acute myeloid leukemia (AML) and ovarian cancer.


Cat. No.: EX-A17094	Purity: >98%

	Chemical structure of CB039

For research only, Do not use for Human!

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CAS No.	3056259-55-0
Purity	>98%
Formula	C23H23N5O5S
Mol Weight	481.524
Color	White to off-white
State	Solid
Solubility	DMSO : 100 mg/mL
Shelf Life	>3 years if stored properly
Storage	Powder 4°C, sealed storage, away from moisture; In solvent -20°C, 1 month.
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Lyu X, et al. Synthesis of an RBM39 Degrader That Downregulates CEP192 and Induces Disorganized Spindle Structures. J Med Chem. 2025 Apr 10;68(7):7807-7826.
CoA	CoA of CB039

Smiles:	CC1=C2C(NC=C2C#N)=C(C=C1)NS(C3=CC=CC(NC(C(N4[C@H](CCC4)CO)=O)=O)=C3)(=O)=O


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