CB-5339

CB-5339 is a second generation, potent and selective, orally bioavailable, ATP-competitive, small molecule inhibitor of valosin containing protein (VCP)/p97 with IC50 of 9 nM.


Cat. No.: EX-A6139	Purity: >98%

	Chemical structure of CB-5339

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
100mg	450	In-stock
250mg	750	In-stock
500mg	1150	In-stock
1g	1800	In-stock
5g	5680	In-stock
10g	7925	In-stock

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Synonyms	p97-IN-1
CAS No.	1863952-15-1
Purity	>98%
Formula	C24H24N6O
Mol Weight	412.487
Color	Off-white to yellow
State	solid powder
Solubility	Soluble in DMSO 100 mg/mL
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Roux, Blandine et al. “Targeting acute myeloid leukemia dependency on VCP-mediated DNA repair through a selective second-generation small-molecule inhibitor.” Science translational medicine vol. 13,587 (2021): eabg1168. doi:10.1126/scitranslmed.abg1168 [2]. Fiskus W C, Das K, Mill C P, et al. Efficacy of Vcp/p97 Inhibitor, CB-5339, Alone and in Combinations Against High-Risk AML, Including Those with Genetic Lesion in TP53[J]. Blood, 2022, 140(Supplement 1): 8807-8808. [3]. Wang X, Wen T, Miao H, et al. Discovery of a new class of valosine containing protein (VCP/P97) inhibitors for the treatment of colorectal cancer[J]. Bioorganic & Medicinal Chemistry, 2022, 74: 117050.
CoA	CoA of CB-5339


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