CB-1158

Numidargistat (CB-1158) is a potent and orally active inhibitor of arginase, with IC50s of 86 nM and 296 nM for recombinant human arginase 1 and recombinant human arginase 2, respectively. Immuno-oncology agent.


Cat. No.: EX-A2679	Purity: >98%

	Chemical structure of CB-1158

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
100mg	1250	In-stock
250mg	2000	In-stock
500mg	3200	In-stock
1g	4800	In-stock

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Synonyms	Numidargistat
Synonyms 2	INCB01158
CAS No.	2095732-06-0
Purity	>98%
Formula	C11H22BN3O5
Mol Weight	287.12
State	solid powder
Solubility	Soluble in DMSO
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Steggerda SM, et al. Inhibition of arginase by CB-1158 blocks myeloid cell-mediated immune suppression in the tumor microenvironment. J Immunother Cancer. 2017 Dec 19;5(1):101.
CoA	CoA of CB-1158

Smiles:	C[C@H](N)C(=O)N1C[C@H](CCCB(O)O)[C@@](N)(C1)C(O)=O


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