Casimersen

Casimersen (SRP-4045) is an antisense oligonucleotide of the phosphorodiamidate morpholino oligomer subclass. Casimersen binds to exon 45 of dystrophin pre-mRNA, restores the open-reading frame (by skipping exon 45) resulting in the production of an internally truncated but functional dystrophin protein. Casimersen can be used for the research of Duchenne muscular dystrophy (DMD).


Cat. No.: EX-A8116	Purity: >95%

	Chemical structure of Casimersen

For research only, Do not use for Human!

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Synonyms	SRP-4045
CAS No.	1422958-19-7
Purity	>95%
Formula	C22H40N7O9P
Mol Weight	577.5683
Color	White to off-white
State	solid powder
Solubility	H2O : 100 mg/mL
Storage	-20℃, stored under nitrogen, away from moisture In solvent : -80℃, 6 months; -20℃, 1 month (stored under nitrogen, away from moisture)
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Shirley M. Casimersen: First Approval. Drugs. 2021;81(7):875-879. [2]. Casimersen. Am J Health Syst Pharm. 2021;78(13):1149-1150.
CoA	CoA of Casimersen


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