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Product Information:

CARM1-IN-6

CARM1-IN-6 is a potent CARM1 inhibitor that inhibits CARM1 enzymatic activity with an IC50 of 12.3 μM and a Kd of 0.6785 μM. CARM1-IN-6 suppresses oncogenic estrogen/ERα-target gene expression, activates type I interferon (IFN) and IFN-induced genes (ISGs), induces cell cycle arrest, and inhibits breast cancer cell proliferation both in vitro and in vivo. CARM1-IN-6 can be used for the research of breast cancer .

Cat. No.: EX-A10223    Purity: >98%
Chemical
Chemical structure of CARM1-IN-6


For research only, Do not use for Human!

SizeUnit Price (US$)StockQuantityOrder
250mg1250In-stock
1g2450In-stock


CAS No.1269199-96-3
Purity>98%
FormulaC23H29N5O
Mol Weight391.5093
ColorWhite to off-white
StateSolid
Solubilitysoluble in DMSO
Shelf Life>3 years if stored properly
StoragePowder -20℃ 3 years, 4℃ 2 years; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Peng BL, et al. A CARM1 Inhibitor Potently Suppresses Breast Cancer Both In Vitro and In Vivo. J Med Chem. 2024;67(10):7921-7934.

CoACoA of CARM1-IN-6
Smiles:CN(C)CCN(CC1)CCN1C2=NC=C(C(C3=CC=C(C)C=C3)=N2)C4=COC=C4

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