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Product Information:

Cantuzumab mertansine

Cantuzumab mertansine (SB-408075; huC242-DM1), an ADC, is an immunoconjugate of the potent maytansine derivative (DM1; HY-19792) and the humanized monoclonal antibody (huC242) directed to CanAg. Cantuzumab mertansine has cytotoxic toward colon cancer cells and has broad antitumor efficacy against a range of CanAg-positive human tumor xenografts .

Cat. No.: EX-A11439    Purity: >98%
Chemical
Chemical structure of Cantuzumab mertansine


For research only, Do not use for Human!

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SynonymsSB-408075
Synonyms 2huC242-DM1
CAS No.400010-39-1
Purity>98%
ColorColorless to light yellow
StateLiquid
StoragePlease store the product under the recommended conditions in the Certificate of Analysis.
ShippingShipped with dry ice.
 
 
Reference:  

[1]. Paul R Helft, et al. A phase I study of cantuzumab mertansine administered as a single intravenous infusion once weekly in patients with advanced solid tumors. Clin Cancer Res. 2004 Jul 1;10(13):4363-8.

[2]. Anthony W. Tolcher, et al. Cantuzumab Mertansine, a Maytansinoid Immunoconjugate Directed to the CanAg Antigen: A Phase I, Pharmacokinetic, and Biologic Correlative Study. J Clin Oncol. 2003 Jan 15;21(2):211-22.

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