CAIIVII-IN-1

CAII/VII-IN-1 is an orally active hCA II (KI = 12.3 nM), and hCA VII (KI = 22.6 nM) inhibitor, showing no significant activity against hCA I. CAII/VII-IN-1 shows excellent neuroprotective activity in vivo Pilocarpine -induced seizure model. CAII/VII-IN-1 can upregulate KCC2 and inhibit mTOR, exerting neuroprotective effects. CAII/VII-IN-1 does not show any significant neurotoxic effects or alterations in liver and kidney function. CAII/VII-IN-1 can be used for the study of epilepsy .


Cat. No.: EX-A15982	Purity: >98%

	Chemical structure of CAIIVII-IN-1

For research only, Do not use for Human!

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CAS No.	3085155-69-4
Purity	>98%
Formula	C27H23ClN8O5S2
Mol Weight	639.105
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. ie Y, et al. Development of potent glutathione transferase Omega-1 inhibitors with applications in inflammation and cancer therapy. Eur J Med Chem. 2025 Dec 5;299:118072.
CoA	CoA of CAIIVII-IN-1

Smiles:	O=C(NN=CC1=CN(N=C1C=2C=CC(Cl)=CC2)C3=CC=C(C=C3)S(=O)(=O)C)C=4N=NN(C5=CC=C(C=C5)S(=O)(=O)N)C4C


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