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Product Information:

C3N-Dbn-Trp2

C3N-Dbn-Trp2 is an inhibitor for ATP-binding cassette transporter ABCB1. C3N-Dbn-Trp2 inhibits the ABCB1-mediated Rhodamine 123 efflux in cells HEK293T and HCT-15 with IC50 of 5.9 µM and 2.2 µM. C3N-Dbn-Trp2 inhibits the Doxorubicin efflux, enhances the cytotoxicity of Doxorubicin in ABCB1-expressing cells.

Cat. No.: EX-A13360    Purity: >98%
Chemical
Chemical structure of C3N-Dbn-Trp2


For research only, Do not use for Human!

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CAS No.2631659-57-7
Purity>98%
FormulaC36H32N4O2
Mol Weight552.6649
StoragePlease store the product under the recommended conditions in the Certificate of Analysis.
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Koh JYP, et al., Exploring bat-inspired cyclic tryptophan diketopiperazines as ABCB1 Inhibitors. Commun Chem. 2024 Jul 13;7(1):158.

CoACoA of C3N-Dbn-Trp2
Smiles:[H][C@@]12N(CC3=CC=CC=C3)C4=CC=CC=C4[C@]1(CC5=CC=CC=C5)C[C@]6([H])N2C([C@@](CC7=CNC8=C7C=CC=C8)([H])NC6=O)=O

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