C188-9

C188-9 (TTI-101) is a STAT3 inhibitor, with a Kd of 4.7 nM. C188-9 inhibits G-CSF-induced STAT3 activation and STAT3-dependent gene expression. C188-9 induces apoptosis in AML cell lines and primary samples and inhibits colony formation by primary AML blasts.


Cat. No.: EX-A1961	Purity: >98%

	Chemical structure of C188-9

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
250mg	600	In-stock
500mg	900	In-stock
1g	1350	In-stock
2g	2400	In-stock
5g	3900	Inqurie
10g	5900	Inqurie

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Synonyms	TTI-101
CAS No.	432001-19-9
Purity	>98%
Formula	C27H21NO5S
Mol Weight	471.524
State	solid powder
Solubility	Soluble in DMSO
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Silva KA, et al. Inhibition of Stat3 activation suppresses caspase-3 and the ubiquitin-proteasome system, leading to preservation of muscle mass in cancer cachexia. J Biol Chem. 2015 Apr 24;290(17):11177-87. [2]. Redell MS, et al. Stat3 signaling in acute myeloid leukemia: ligand-dependent and -independent activation and induction of apoptosis by a novel small-molecule Stat3 inhibitor. Blood. 2011 May 26;117(21):5701-9. [3]. Bharadwaj U, et al. Small-molecule inhibition of STAT3 in radioresistant head and neck squamous cell carcinoma. Oncotarget. 2016 May 3;7(18):26307-30. [4]. Redell MS, et al. Stat3 signaling in acute myeloid leukemia: ligand-dependent and -independent activation and induction of apoptosis by a novel small-molecule Stat3 inhibitor. Blood. 2011;117(21):5701-5709.
CoA	CoA of C188-9

Smiles:	COC1=CC=C(C=C1)S(=O)(=O)NC1=CC(=C(O)C2=CC=CC=C12)C1=C(O)C=CC2=CC=CC=C12


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