c-Met degrader-1

c-Met degrader-1 (Compound H11) is an orally active c-Met degrader (through the ubiquitin proteasome system). c-Met degrader-1 has anti-hepatocellular carcinoma activity (HCC) and inhibits tumor growth in MHCC97H xenografts. c-Met degrader-1 inhibits HCC cell growth, arrests cell cycle, and induces apoptosis. c-Met degrader-1 may overcome resistance to type Ib inhibitors.


Cat. No.: EX-A11995	Purity: >98%

	Chemical structure of c-Met degrader-1

For research only, Do not use for Human!

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Purity	>98%
Formula	C45H53N7O3
Mol Weight	739.9474
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Min W, et al. Discovery of Potent and Selective c-Met Degraders for Hepatocellular Carcinoma Treatment. J Med Chem. 2024 Jul 4.
CoA	CoA of c-Met degrader-1

Smiles:	C1CN(CCC1COC2=CN=C(N=C2)C3=CC=CC(=C3)CN4C(=O)C=CC(=N4)C5=CC=CC(=C5)C#N)CCCCCC(=O)NCC67CC8CC(C6)CC(C8)C7


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