c-di-AMP disodium

c-di-AMP (Cyclic diadenylate) sodium is a STING agonist, which binds to the transmembrane protein STING thereby activating the TBK3-IRF3 signaling pathway, subsequently triggering the production of type I IFN and TNF. c-di-AMP sodium is also a bacterial second messenger, which regulates cell growth, survival, and virulence, primarily within Gram-positive bacteria, and also regulates host immune response. c-di-AMP sodium acts as a potent mucosal adjuvant stimulating both humoral and cellular responses.


Cat. No.: EX-A6958	Purity: >98%

	Chemical structure of c-di-AMP disodium

For research only, Do not use for Human!

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CAS No.	2734909-87-4
Purity	>98%
Formula	C20H25N10NaO12P2
Mol Weight	682.4096
Color	White to off-white
State	solid powder
Solubility	Soluble in DMSO 270 mg/mL H2O ? 50 mg/mL
Shelf Life	>2 years if stored properly
Storage	Powder -80°C, protect from light, stored under nitrogen.
Shipping	Shipping with dry ice.

Reference:	[1]. Fahmi T, et al. c-di-AMP: An Essential Molecule in the Signaling Pathways that Regulate the Viability and Virulenceof Gram-Positive Bacteria. Genes (Basel). 2017 Aug 7;8(8). [2]. Ning H, et al. Recombinant BCG With Bacterial Signaling Molecule Cyclic di-AMP as Endogenous AdjuvantInduces Elevated Immune Responses After Mycobacterium tuberculosis Infection. Front Immunol. 2019 Jul 3;10:1519. [3]. Ebensen T, et al. The Combination Vaccine Adjuvant System Alum/c-di-AMP Results in Quantitative and QualitativeEnhanced Immune Responses Post Immunization. Front Cell Infect Microbiol. 2019 Feb 19;9:31. [4]. Sanchez MV, et al. Intranasal delivery of influenza rNP adjuvanted with c-di-AMP induces strong humoral and cellularimmune responses and provides protection against virus challenge. PLoS One. 2014 Aug 20;9(8):e104824.
CoA	CoA of c-di-AMP disodium


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