BuChE-IN-TM-10

BuChE-IN-TM-10 (TM-10) is a potent butyrylcholinesterase (BuChE) inhibitor, with an IC50 of 8.9 nM. BuChE inhibitor 1 inhibits and disaggregates self-induced Aβ aggregation, exhibiting potent antioxidant activity and good blood-brain barrier (BBB) penetration. Has potential to treat Alzheimer's disease.


Cat. No.: EX-A8339	Purity: >98%

	Chemical structure of BuChE-IN-TM-10

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
10mg	482	in_stock
25mg	726	in_stock
100mg	1416	in_stock
250mg	2151	in_stock
500mg	3075	in_stock
1g	4139	in_stock

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Synonyms	TM-10
CAS No.	2313524-95-5
Purity	>98%
Formula	C32H38N2O3
Mol Weight	498.6557
State	solid powder
Solubility	Soluble in DMSO
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Sang Z, et al. Design, Synthesis, and Evaluation of Novel Ferulic Acid Derivatives as Multi-Target-Directed Ligands for the Treatment of Alzheimer's Disease. ACS Chem Neurosci. 2019 Feb 20;10(2):1008-1024.
CoA	CoA of BuChE-IN-TM-10

Smiles:	COC(C=C1/C=C/C(N2CC3=CC=CC=C3CC2)=O)=C(C=C1)OCCCCN(CC)CC4=CC=CC=C4


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