BTX161

BTX161, a Thalidomide (HY-14658) analog, is a molecular glue degrader targeting CK1α. BTX161 recruits CK1α and the CK1α-FAM83 complex to the Cul4ACRBN E3 ligase complex, thereby driving ubiquitination and proteasomal degradation. BTX161 reduces FAM83G abundance through CK1α-FAM83G co-stability, slightly decreases FAM83H levels, but has no effect on the expression of FAM83B. BTX161 activates DNA damage response (DDR) and upregulates Wnt target genes including MYC. BTX161 can be used in research related to colorectal cancer, type b myelomonocytic leukemia and acute myeloid leukemia .


Cat. No.: EX-A17543	Purity: >98%

	Chemical structure of BTX161

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
100mg	1350	Inquire
250mg	2350	Inquire
500mg	3550	Inquire
1g	4980	Inquire

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CAS No.	2052301-24-1
Purity	>98%
Formula	C15H16N2O3
Mol Weight	272.2991
Color	White to off-white
State	Solid
Solubility	Soluble in DMSO
Shelf Life	>3 years if stored properly
Storage	Powder -20°C, 3 years , 4°C, 2 years ; In solvent -20°C, 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1].a href="https://pubmed.ncbi.nlm.nih.gov/33361334" rel="nofollow" target="_blank">Dunbar K, et al. IMiDs induce FAM83F degradation via an interaction with CK1α to attenuate Wnt signalling. Life science alliance. 2021 Feb;4(2):e202000804. [2].Glennie L, et al. The Contribution of Native Protein Complexes to Targeted Protein Degradation. ACS Chem Biol. 2026 May 15;21(5):1095-1111. [3].Minzel W, et al. Small Molecules Co-targeting CKIα and the Transcriptional Kinases CDK7/9 Control AML in Preclinical Models. Cell. 2018 Sep 20;175(1):171-185.e25.
CoA	CoA of BTX161

Smiles:	O=C([C@@H](N(CC1=C2C=CC=C1C)C2=O)CCC3)NC3=O


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