BT173

BT173 is a potent homeodomain interacting protein kinase 2 (HIPK2) inhibitor. BT173 binds to HIPK2 and does not inhibit HIPK2 kinase activity but rather, interfered allosterically with the ability of HIPK2 to associate with Smad3. BT173 attenuates renal fibrosis through suppression of the TGF-β1/Smad3 pathway. BT173 can be studied in research for kidney diseases such as renal fibrosis.


Cat. No.: EX-A5764	Purity: >98%

	Chemical structure of BT173

For research only, Do not use for Human!

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CAS No.	2232180-74-2
Purity	>98%
Formula	C18H12BrN3O2
Mol Weight	382.211
Color	White to light yellow
State	solid powder
Solubility	Soluble in DMSO 2 mg/mL
Shelf Life	>2 years if stored properly
Storage	Powder -20°C, protect from light; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Ruijie Liu, et al. A Novel Inhibitor of Homeodomain Interacting Protein Kinase 2 Mitigates Kidney Fibrosis through Inhibition of the TGF- β 1/Smad3 Pathway. J Am Soc Nephrol. 2017 Jul;28(7):2133-2143.
CoA	CoA of BT173


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