BRL 44408

BRL-44408 is a selective, blood-brain barrier-permeable α2A-adrenergic receptor antagonist with a Ki value of 8.56 nM against human targets. BRL-44408 exhibits activities such as antidepressant, analgesic effects and attenuation of sepsis-induced acute lung injury by regulating the release of neurotransmitters such as norepinephrine and dopamine, or inhibiting signaling pathways including ERK1/2, p38MAPK and p65. BRL-44408 can be used in studies related to acute respiratory distress syndrome, depression and visceral pain .


Cat. No.: EX-A17141	Purity: >98%

	Chemical structure of BRL 44408

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
10mg	364	in_stock
25mg	745	in_stock
50mg	1164	in_stock
100mg	1883	in_stock
250mg	3686	in_stock
500mg	5988	in_stock

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CAS No.	118343-19-4
Purity	>98%
Formula	C13H17N3
Mol Weight	215.2942
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Cong Z, et al. α_2A -AR antagonism by BRL-44408 maleate attenuates acute lung injury in rats with downregulation of ERK1/2, p38MAPK, and p65 pathway. J Cell Physiol. 2020;235(10):6905-6914. [2]. Dwyer JM, et al. Preclinical characterization of BRL 44408: antidepressant- and analgesic-like activity through selective alpha2A-adrenoceptor antagonism. Int J Neuropsychopharmacol. 2010;13(9):1193-1205. [3]. Further Studies on a2-Adrenofeptor Subtypes Involved in the Modulation of [ HINoradrenaline and [3H]5-Hydroxytryptamine Release from Rat Brain Cortex Synaptosomes
CoA	CoA of BRL 44408

Smiles:	CC1N(CC2=NCCN2)CC3=C1C=CC=C3


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