BRD5080

BRD5080 is a GPR65 agonist. BRD5080 activates GPR65 to enhance the cAMP signaling pathway, reduce the expression of inflammatory cytokines and chemokines in dendritic cells, enhance the activity of human wild-type, mouse wild-type, and human GPR65I231L variant receptors in a pH-dependent manner, and mediate the recruitment of Gαs protein. BRD5080 can be used in the research of inflammatory bowel disease.


Cat. No.: EX-A11994	Purity: >98%

	Chemical structure of BRD5080

For research only, Do not use for Human!

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Purity	>98%
Formula	C24H23FN4O3
Mol Weight	434.4628
Color	Off-white to light brown
State	Solid
Solubility	DMSO : 100 mg/mL
Shelf Life	>3 years if stored properly
Storage	Powder -20°C, 3 years; In solvent -20°C, 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Justus CR, et al. The Roles of Proton-Sensing G-Protein-Coupled Receptors in Inflammation and Cancer. Genes (Basel). 2024 Sep 1;15(9):1151. [2]. Neale I, et al. Small-molecule probe for IBD risk variant GPR65 I231L alters cytokine signaling networks through positive allosteric modulation. Science Advances. 2024;10(29):eadn2339.
CoA	CoA of BRD5080

Smiles:	CC1=CC(=C(C=C1)NC(=O)C2=CNN3C2=NC(=CC3=O)C4=CC=C(C=C4)COC(C)C)F


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