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Product Information:

BRD4 degrader-1

BRD4 degrader-1 (Compound mL 1-50) is a relatively selective, monovalent and covalent BRD4 Molecular glue degrader. BRD4 degrader-1 induces degradation of both long and short isoforms of BRD4 by targeting DCAF16 (an E3 ligase). BRD4 degrader-1 can be used in breast cancer research .

Cat. No.: EX-A16787    Purity: >98%
Chemical
Chemical structure of BRD4 degrader-1


For research only, Do not use for Human!

SizeUnit Price (US$)StockQuantityOrder
25mgget quote


CAS No.3094209-54-5
Purity>98%
FormulaC25H27ClN6O3S2
Mol Weight559.103
Colorwhite to off-white
Statesolid
SolubilityDMSO : >50 mg/mL
Shelf Life>3 years if stored properly
StoragePowder -20°C, sealed storage, 3 years; 4°C, sealed storage, 2 years; In solvent :20°C, 1 month (protect from light)
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Lim M, et al. DCAF16-Based Covalent Handle for the Rational Design of Monovalent Degraders. ACS Cent Sci. 2024;10(7):1318-1331. Published 2024 May 17.

CoACoA of BRD4 degrader-1
Smiles:O=C(N1CCN(S(=O)(C=C)=O)CC1)C[C@H]2C3=NN=C(C)N3C4=C(C(C)=C(C)S4)C(C5=CC=C(Cl)C=C5)=N2

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