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Product Information:

BPR1K871

BPR1K871 (DBPR-114) is a potent and selective dual FLT3/AURKA inhibitor with IC50s of 19 nM and 22 nM for FLT3 and AURKA, respectively.

Cat. No.: EX-A1135    Purity: >98%
Chemical
Chemical structure of BPR1K871


For research only, Do not use for Human!

SizeUnit Price (US$)StockQuantityOrder
250mg1150In-stock
500mg1780In-stock
1g2650In-stock


SynonymsDBPR-114
CAS No.2443767-35-7
Purity>98%
FormulaC25H28ClN7O2S
Mol Weight526.054
Colorwhite to off-white
Statepowder
SolubilitySoluble in DMSO
Shelf Life>2 years if stored properly
StoragePowder -20℃ 3 years; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:   [1]. Hsu YC, et al. Discovery of BPR1K871, a quinazoline based, multi-kinase inhibitor for the treatment of AML and solid tumors: Rational design, synthesis, in vitro and in vivo evaluation. 2016 Dec 27; 7(52): 86239–86256.
CoACoA of BPR1K871
Smiles:CN(C)CCCOC1=CC=C2C(NCCC3=CN=C(NC(=O)NC4=CC=CC(Cl)=C4)S3)=NC=NC2=C1

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