BMX-IN-1

BMX-IN-1 is a selective, irreversible inhibitor of bone marrow tyrosine kinase on chromosome X (BMX) that targets Cys496 in the BMX ATP binding domain with an IC50 of 8 nM, also targets the related Bruton’s tyrosine kinase (BTK) with an IC50 value of 10.4 nM, but is more than 47-656-fold less potent against Blk, JAK3, EGFR, Itk, or Tec activity.


Cat. No.: EX-A6712	Purity: >98%

	Chemical structure of BMX-IN-1

For research only, Do not use for Human!

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CAS No.	1431525-23-3
Purity	>98%
Formula	C29H24N4O4S
Mol Weight	524.59
Color	White to yellow
State	solid powder
Solubility	Soluble in DMF 10 mg/mL DMSO 8.33 mg/mL
Shelf Life	>3 years if stored properly
Storage	Powder -20℃ 3 years, 4°C 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Feiyang Liu , et al. Discovery of a Selective Irreversible BMX Inhibitor for Prostate Cancer. ACS Chem. Biol., DOI: 10.1021/cb4000629
CoA	CoA of BMX-IN-1


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