BMS-986458

BMS-986458 is a highly selective and orally active BCL6 PROTAC degrader. BMS-986458 simultaneously co-opts cereblon (CRBN) and the BCL6 N-terminal BTB domain to catalyze proximity induced degradation of BCL6.


Cat. No.: EX-A12465	Purity: >98%

	Chemical structure of BMS-986458

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
10mg	320	In-stock
25mg	630	In-stock
50mg	990	In-stock
100mg	1600	In-stock
250mg	3100	In-stock
500mg	5160	In-stock

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CAS No.	3005272-36-3
Purity	>98%
Formula	C32H34ClN9O3
Mol Weight	628.124
State	solid powder
Shelf Life	>3 years if stored properly
Storage	Powder 4℃, sealed storage, away from moisture, 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Lynda Groocock, et al. BMS-986458 a Potential First-in-Class, Highly Selective, Potent and Well Tolerated BCL6 Ligand Directed Degrader (LDD) Demonstrates Multi-Modal Anti-Tumor Efficacy for the Treatment of B-Cell Non-Hodgkin's Lymphoma. Blood. Volume 144, Supplement 1, 5 November 2024, Page 957.
CoA	CoA of BMS-986458


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