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Product Information:

BMS-986408

BMS-986408 is an orally available dual DGK α/ζ inhibitor that restores T cell-mediated anti-tumor immunity by enhancing T cell signaling.

Cat. No.: EX-A9766    Purity: >98%
Chemical
Chemical structure of BMS-986408


For research only, Do not use for Human!

SizeUnit Price (US$)StockQuantityOrder
100mg5500Inquire
250mg7800Inquire


CAS No.2618418-12-3
Purity>98%
FormulaC26H29F3N6O
Mol Weight498.5433
ColorOff-white to light brown
Statesolid
SolubilitySoluble in DMSO
Shelf Life>3 years if stored properly
StoragePowder 2-8 ℃ 2 years; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Wichroski M, et al. Discovery of BMS-986408, a First-In-Class Dual DGKα and DGKζ Inhibitor That Unleashes PD-1 Checkpoint and CAR T-Cell Immunotherapies. Cancer Immunol Res. 2025 Jun 12.

CoACoA of BMS-986408
Smiles:CC[C@H]1CN([C@@H](CN1C2=NC(N(C3=CC=C(N=C32)C#N)C)=O)CC)[C@H](C4=CC=C(C=C4)C(F)(F)F)CC

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