BMS-986365

BMS-986365 (CC-94676) is a selective heterobifunctional ligand-directed degrader (LDD) targeting the androgen receptor (AR). BMS-986365 (CC-94676) demonstrated significant in vivo potency, degrading AR, inhibiting AR signaling, and inhibiting tumor growth in animal models of advanced prostate cancer.


Cat. No.: EX-A8829	Purity: >98%

	Chemical structure of BMS-986365

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
100mg	750	In-stock
250mg	1400	In-stock
500mg	2200	In-stock
1g	3520	In-stock
2g	4860	In-stock
5g	get quote	In-stock

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Synonyms	CC-94676
CAS No.	2446928-30-7
Purity	>98%
Formula	C41H45F3N8O5S
Mol Weight	818.907
Color	White to off-white
State	solid
Solubility	Soluble in DMSO
Shelf Life	>3 years if stored properly
Storage	Powder 4℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Xu S, et al. Abstract ND02: Discovery of BMS-986365, a ligand-directed androgen receptor degrader (AR LDD) with a dual mechanism-of-action and best-in-class potential, for the treatment of advanced prostate cancer[J]. Cancer Research, 2024, 84(7_Supplement): ND02-ND02.
Data Sheet	Data sheet of BMS-986365
CoA	CoA of BMS-986365
SDS	SDS of BMS-986365

Smiles:	S=C1N(C(=O)C(C)(C)N1C2=CC(CC)=C(OCCN3C[C@@H](C)N(CC(NC4=CC(NC5C(=O)NC(=O)CC5)=CC=C4)=O)CC3)C=C2)C6=CC(C(F)(F)F)=C(C#N)C=C6


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