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Product Information:

BMS-690514

BMS-690514 is a potent and orally active inhibitor of EGFR and VEGFR; has IC50s of 5, 20 and 60 nM for EGFR, HER 2 and HER 4, respectively.

Cat. No.: EX-A11144    Purity: >98%
Chemical
Chemical structure of BMS-690514


For research only, Do not use for Human!

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CAS No.859853-30-8
Purity>98%
FormulaC19H24N6O2
Mol Weight368.4329
ColorWhite to off-white
Statesolid
SolubilityDMSO : ? 25 mg/mL
Shelf Life>3 years if stored properly
StoragePowder -20℃ 3 years; 4℃, 2 years; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Wong TW, et al. Antitumor and antiangiogenic activities of BMS-690514, an inhibitor of human EGF and VEGF receptor kinase families. Clin Cancer Res. 2011 Jun 15;17(12):4031-41.

[2]. Marathe P, et al. Preclinical pharmacokinetics and in vitro metabolism of BMS-690514, a potent inhibitor of EGFR and VEGFR2. J Pharm Sci. 2010 Aug;99(8):3579-93.

CoACoA of BMS-690514
Smiles:O[C@@H]1CN(CC[C@H]1N)CC2=C3C(NC4=CC=CC(OC)=C4)=NC=NN3C=C2

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