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Product Information:

BMS-615

TLR7/8/9-IN-1 (BMS-615) is a potent and orally bioavailable small molecule antagonist (IC50 = 43 nM) of Toll-like receptors 7/8/9 (TLR7/8/9).

Cat. No.: EX-A3290    Purity: >98%
Chemical
Chemical structure of BMS-615


For research only, Do not use for Human!

SizeUnit Price (US$)StockQuantityOrder
100mg600In-stock
200mg900In-stock
500mg1500In-stock
1g2500Inquire
5g7500Inquire


SynonymsTLR7/8/9-IN-1
CAS No.2180127-82-4
Purity>98%
FormulaC27H37N3O2
Mol Weight435.6016
Statesolid powder
SolubilityDMSO : 83.33 mg/mL (191.30 mM; ultrasonic and warming and heat to 60?)
Shelf Life>3 years if stored properly
StoragePowder 4℃ 2 years; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Mussari CP, et al. Discovery of Potent and Orally Bioavailable Small Molecule Antagonists of Toll-like Receptors 7/8/9 (TLR7/8/9). ACS Med Chem Lett. 2020 Jul 29;11(9):1751-1758.

CoACoA of BMS-615
Smiles:CC(C)C1=C(C2=CC=C(OC)C(OC)=C2)NC3=CC=C(C4CCN(CCNC)CC4)C=C31

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