BMS 299897

BMS 299897 is a sulfonamide γ-secretase inhibitor with an IC50 of 7 nM for Aβ production inhibition in HEK293 cells stably overexpressing amyloid precursor protein (APP).


Cat. No.: EX-A7260	Purity: >98%

	Chemical structure of BMS 299897

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
100mg	425	In-stock
250mg	812	In-stock
500mg	1358	In-stock
1g	2276	In-stock
5g	get quote	In-stock
10g	get quote	In-stock

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Synonyms	BMS299897
Synonyms 2	BMS-299897
CAS No.	290315-45-6
Purity	>98%
Formula	C24H21ClF3NO4S
Mol Weight	511.941
Color	white to off-white
State	solid powder
Solubility	DMSO : ? 30 mg/mL
Shelf Life	>3 years if stored properly
Storage	Powder -20°C, 3 years , 4°C, 2 years ; In solvent -20°C, 1 year
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Meunier J, et al. The γ-secretase inhibitor 2-[(1R)-1-[(4-chlorophenyl)sulfonyl](2,5-difluorophenyl) amino]ethyl-5-fluorobenzenebutanoic acid (BMS-299897) alleviates Aβ1-42 seeding and short-term memory deficits in the Aβ25-35 mouse model of Alzheimer's d [2]. Weissmiller AM, et al. A γ-secretase inhibitor, but not a γ-secretase modulator, induced defects in BDNF axonal trafficking and signaling: evidence for a role for APP. PLoS One. 2015 Feb 24;10(2):e0118379.
CoA	CoA of BMS 299897


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