BMH-22

BMH-22, a benzonaphthyridin, is a RNA polymerase I (Pol I) transcription inhibitor independent of p53 function. BMH-22 causes reorganization of nucleolar marker proteins consistent with segregation of the nucleolus. BMH-22 destabilizes RPA194 in a proteasome-dependent manner and inhibits nascent rRNA synthesis and expression of the 45S rRNA precursor. BMH-22 shows potent anticancer activity across many tumor types .


Cat. No.: EX-A10294	Purity: >98%

	Chemical structure of BMH-22

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
250mg	885	In-stock
500mg	1285	In-stock
1g	1885	In-stock

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CAS No.	309726-06-5
Purity	>98%
Formula	C16H17N3
Mol Weight	251.3263
Color	Light yellow to yellow
State	Solid
Solubility	Soluble in DMSO
Shelf Life	>3 years if stored properly
Storage	Powder -20℃ 3 years, 4℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. RPA194, rRNA synthesis, 45S Rrna, anticancer Karita Peltonen, et al. Small molecule BMH-compounds that inhibit RNA polymerase I and cause nucleolar stress. Mol Cancer Ther. 2014 Nov;13(11):2537-46.
CoA	CoA of BMH-22

Smiles:	CC1=C2N=C3N=C(C=C(C3=C(C2=CC(C)=C1)N)C)C


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