BLU-451

BLU-451 is a CNS penetrant, wild type-sparing, covalent small molecule investigational inhibitor of EGFR ex20ins as well as atypical (G719C, G719S, L861Q) and common EGFR mutants.


Cat. No.: EX-A8441	Purity: >98%

	Chemical structure of BLU-451

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
5mg	485	In-stock
10mg	650	In-stock
25mg	850	In-stock
50mg	1150	In-stock
100mg	1550	In-stock
200mg	2150	In-stock

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Synonyms	LNG451
CAS No.	2769954-39-2
Purity	>98%
Formula	C24H19F4N7O
Mol Weight	497.4476
Color	White to off-white
State	solid powder
Solubility	DMSO : 116.67 mg/mL
Shelf Life	>3 years if stored properly
Storage	Powder -20°C, 3 years , 4°C, 2 years ; In solvent -20°C, 1 month
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. A. Spira, H. Yu, L. Sun, D. Nguyen, J. Parepally, F. Albayya, S. Patel, H. Zhang, A. Zalutskaya, X. Le. EP08.02-018 Phase 1/2 Study of BLU-451, a Small Molecule Inhibitor of EGFR, in EGFR Exon 20 Insertion-Mutant Incurable Advanced Cancers. Journal of Thoracic Oncology, Volume 17, Issue 9, Supplement, 2022, Pages S405-S406, ISSN 1556-0864, doi.org/10.1016/j.jtho.2022.07.700.
CoA	CoA of BLU-451

Smiles:	C=CC(NC1=CC=C(F)C(NC2=NC(NC3=CN(C)N=C3)=NC=C2C4=CC=C(C(F)(F)F)C=C4)=C1)=O


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