BJP-07-017-3

BJP-07-017-3 is the inhibitor for proline cis trans isomerase (Pin1) with an IC50 of 9 nM. BJP-07-017-3 forms covalent bond with Cys113 of Pin1, induces conformational changes in Pin1, reduces its stability, and leads to a proteasome-dependently degradation.


Cat. No.: EX-A13031	Purity: >98%

	Chemical structure of BJP-07-017-3

For research only, Do not use for Human!

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CAS No.	2468783-22-2
Purity	>98%
Formula	C35H45ClN8O6
Mol Weight	709.235
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Alboreggia G, et al., Targeted degradation of Pin1 by protein-destabilizing compounds. Proc Natl Acad Sci U S A. 2024 Nov 19;121(47):e2403330121.
CoA	CoA of BJP-07-017-3

Smiles:	C([C@H](NC(=O)[C@H]1N(C([C@H](CC2=CC=CC=C2)N(C(CCl)=O)C)=O)CCCC1)C(N[C@@H](CCCNC(N)=O)C(N)=O)=O)C=3C=4C(NC3)=CC=CC4


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