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Bisindolylmaleimide XI hydrochloride

Bisindolylmaleimide XI hydrochloride (Ro 32-0432) is a potent, selective and orally active PKC inhibitor with IC50s of 9 nM, 28 nM, 31 nM, 37 nM, and 108 nM for PKCα, PKCβI, PKCβII, PKCγ, and PKCε, respectively.

Cat. No.: EX-A11217    Purity: >98%
Chemical
Chemical structure of Bisindolylmaleimide XI hydrochloride


For research only, Do not use for Human!

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SynonymsRo 32-0432
Synonyms 2Ro 31-8830 hydrochloride
CAS No.145333-02-4
Purity>98%
FormulaC28H29ClN4O2
Mol Weight489.008
ColorYellow to orange
Statesolid
SolubilityDMSO : 5 mg/mL
Shelf Life>3 years if stored properly
StoragePowder -20°C, sealed storage, away from moisture; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. S E Wilkinson, et al. Isoenzyme specificity of bisindolylmaleimides, selective inhibitors of protein kinase C. Biochem J. 1993 Sep 1;294 ( Pt 2)(Pt 2):335-7.

[2]. A M Birchall, et al. Ro 32-0432, a selective and orally active inhibitor of protein kinase C prevents T-cell activation. J Pharmacol Exp Ther. 1994 Feb;268(2):922-9.

[3]. Roman Kholodenko, et al. Anti-apoptotic effect of retinoic acid on retinal progenitor cells mediated by a protein kinase A-dependent mechanism. Cell Res. 2007 Feb;17(2):151-62.

CoACoA of Bisindolylmaleimide XI hydrochloride
Smiles:O=C(NC1=O)C(C2=C3CC(CCN3C4=C2C=CC=C4)CN(C)C)=C1C5=CN(C6=C5C=CC=C6)C.Cl

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