Bisindolylmaleimide X hydrochloride

Bisindolylmaleimide X hydrochloride(Ro 31-8425 hydrochloride, BIM-X hydrochloride) is a cell-penetrating PKC inhibitor. Bisindolylmaleimide X hydrochloride is a potent cyclin-dependent kinase 2 (CDK2) antagonist with an IC50 of 200 nM. Bisindolylmaleimide X hydrochloride inhibits the proliferation of CD4 T cells in vitro. Bisindolylmaleimide X hydrochloride inhibits eNOS-Ser1177 phosphorylation in human embryonic vein endothelial cells. Bisindolylmaleimide X hydrochloride can be used for research on the immune system and cardiovascular diseases.


Cat. No.: EX-A11135	Purity: >98%

	Chemical structure of Bisindolylmaleimide X hydrochloride

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
100mg	795	Inquire
250mg	1352	Inquire
500mg	2165	Inquire
1g	3468	Inquire

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Synonyms	BIM-X hydrochloride
Synonyms 2	Ro31-8425 hydrochloride
CAS No.	145317-11-9
Purity	>98%
Formula	C26H25ClN4O2
Mol Weight	460.955
Color	Light yellow to orange
State	solid
Solubility	DMSO : 20.83 mg/mL H2O : < 0.1 mg/mL
Shelf Life	>3 years if stored properly
Storage	Powder 4°C, sealed storage, away from moisture and light; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Levy O, et al. A cell-based drug delivery platform for treating central nervous system inflammation. J Mol Med (Berl). 2021 May;99(5):663-671. [2]. Song W, et al. Icariside II induces rapid phosphorylation of endothelial nitric oxide synthase via multiple signaling pathways. PeerJ. 2022 Oct 25;10:e14192. [3]. Brehmer D, et al. Proteome-wide identification of cellular targets affected by bisindolylmaleimide-type protein kinase C inhibitors. Mol Cell Proteomics. 2004 May;3(5):490-500.
CoA	CoA of Bisindolylmaleimide X hydrochloride

Smiles:	O=C(C(C1=C(CC(CN)CC2)N2C3=C1C=CC=C3)=C4C5=CN(C)C6=C5C=CC=C6)NC4=O.[H]Cl


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