Biotin-(Oaa)3-epoxomicin

Biotin-(Oaa)3-epoxomicin is a biotin-labeled form of Epoxomicin , prepared by conjugating Epoxomicin with biotin via three hydrophilic oxaacetyl amino acid (Oaa) linkers. Biotin-(Oaa)3-epoxomicin is primarily used in proteomic studies for the capture, identification and target validation of proteasome complexes, to determine the intracellular targets of epoxomicin. Epoxomicin acts as a proteasome inhibitor and NF-κB inhibitor, which effectively blocks inflammatory responses in mouse ear edema assays. It inhibits proteasome activity via covalent binding to catalytic subunits including LMP7, X, MECL1 and Z, with the strongest inhibitory effect on chymotrypsin-like activity, and does not interfere with non-proteasomal proteases such as trypsin and papain .


Cat. No.: EX-A15845	Purity: >98%

	Chemical structure of Biotin-(Oaa)3-epoxomicin

For research only, Do not use for Human!

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CAS No.	247068-92-4
Purity	>98%
Formula	C54H95N9O11S
Mol Weight	1078.451
Color	White to off-white
State	Solid
Solubility	soluble in DMSO
Shelf Life	>3 years if stored properly
Storage	Powder -20°C, sealed storage, away from moisture, 1 year; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Meng L, et al. Epoxomicin, a potent and selective proteasome inhibitor, exhibits in vivo antiinflammatory activity. Proc Natl Acad Sci U S A. 1999;96(18):10403-10408. [2]. Hanada M, et al. Epoxomicin, a new antitumor agent of microbial origin. J Antibiot (Tokyo). 1992;45(11):1746-1752.
CoA	CoA of Biotin-(Oaa)3-epoxomicin

Smiles:	C(CCCC(NCCCCCC(NCCCCCC(NCCCCCC(N([C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(=O)[C@@]1(C)CO1)CC(C)C)=O)[C@@H](C)O)=O)[C@H](CC)C)=O)[C@H](CC)C)C)=O)=O)=O)=O)[C@H]2[C@@]3([C@](CS2)(NC(=O)N3)[H])[H]


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