BIO-2007817

BIO-2007817 is a Parkin positive allosteric modulators (PAMs). BIO-2007817 enhances the activity of wildtype Parkin. BIO-2007817 stimulates Parkin (an E3 ligase)autoubiquitination and induces the appearance of monoubiquitinated forms of Miro1 (EC50: 0.17 μM).


Cat. No.: EX-A12258	Purity: >98%

	Chemical structure of BIO-2007817

For research only, Do not use for Human!

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Purity	>98%
Formula	C32H36N6O3
Mol Weight	552.6666
Color	White to off-white
State	Solid
Solubility	DMSO : 50 mg/mL
Shelf Life	>3 years if stored properly
Storage	Powder -20°C, 3 years , 4°C, 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Shlevkov E, et al. Discovery of small-molecule positive allosteric modulators of Parkin E3 ligase. iScience. 2021 Dec 18;25(1):103650.
CoA	CoA of BIO-2007817

Smiles:	CO[C@@H](C1=CN(N=C1)C)C(N2CC3=C(C=NN3C[C@H]2C(C)C)C4=CC=C(C=C4)C(N5CCCC6=C5C=CC=C6)=O)=O


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