BIMU 8

BIMU 8 is a potent and selective 5-HT4 agonist with EC50s of 18 nM, 77 nM, and 540 nM for wild type 5HT4 receptor, T3.36A, and W6.48A mutant 5-HT4 receptors[1][2].


Cat. No.: EX-A14467	Purity: >98%

	Chemical structure of BIMU 8

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
100mg	675	In-stock
250mg	1175	In-stock
500mg	1820	In-stock
1g	2750	In-stock

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CAS No.	134296-40-5
Purity	>98%
Formula	C19H27ClN4O2
Mol Weight	378.896
Color	White to off-white
State	Solid
Solubility	soluble in DMSO
Storage	Powder -20°C, sealed storage, away from moisture; In solvent -20°C, 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. C Ghelardini, et al. Central cholinergic antinociception induced by 5HT4 agonists: BIMU 1 and BIMU 8. Life Sci. 1996;58(25):2297-309. [2]. Lucie P Pellissier, et al. Conformational toggle switches implicated in basal constitutive and agonist-induced activated states of 5-hydroxytryptamine-4 receptors. Mol Pharmacol. 2009 Apr;75(4):982-90. [3]. H Pan , et al. 5-HT1A and 5-HT4 receptors mediate inhibition and facilitation of fast synaptic transmission in enteric neurons. Am J Physiol. 1994 Feb;266(2 Pt 1):G230-8.
CoA	CoA of BIMU 8

Smiles:	CC(C)N1C2=CC=CC=C2N(C1=O)C(=O)NC3C[C@H]4CC[C@@H](C3)N4C.Cl


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