BIIB129

BIIB129 is a covalent, selective, small molecule inhibitor of Bruton's tyrosine kinase (BTK). BIIB129 inhibits the activity of BTK by covalently binding to Cys481 in BTK.


Cat. No.: EX-A9250	Purity: >98%

	Chemical structure of BIIB129

For research only, Do not use for Human!

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CAS No.	2770960-52-4
Purity	>98%
Formula	C19H22N6O2
Mol Weight	366.417
Color	White to off-white
State	solid
Solubility	Soluble in H2O
Shelf Life	>3 years if stored properly
Storage	Powder -20℃ 3 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Himmelbauer M K, et al. Discovery and Preclinical Characterization of BIIB129, a Covalent, Selective, and Brain-Penetrant BTK Inhibitor for the Treatment of Multiple Sclerosis[J]. Journal of Medicinal Chemistry, 2024.
CoA	CoA of BIIB129

Smiles:	CN([C@H]1C[C@](C)(C1)OC1=NC(=CN2N=CC=C12)C1=CN(C)N=C1)C(=O)C=C


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