BIEGi-1

BIEGi-1 is an EGFR inhibitor. BIEGi-1 effectively disrupts the EGFR-Rheb interaction in cells. BIEGi-1 robustly inhibits EGFR kinase activity (reduces p-Y1068-EGFR) as well as mTORC1 activation (reduces p-T389-S6K1) in EGFR-mutant cells. BIEGi-1 shows strong antiproliferative effects on EGFR-mutant PC9 and HCC827 cells with IC50 values of 17 nM and 20 nM, respectively. BIEGi-1 can be used for the study of cancers harboring EGFR mutations, such as non-small cell lung cancer (NSCLC).


Cat. No.: EX-A13970	Purity: >98%

	Chemical structure of BIEGi-1

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
10mg	485	In-stock
25mg	650	In-stock
50mg	885	In-stock
100mg	1285	In-stock
500mg	2285	In-stock
1g	3385	In-stock

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CAS No.	1429497-30-2
Purity	>98%
Formula	C36H37N7O3
Mol Weight	615.7241
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. He X, et al. Lysosomal EGFR acts as a Rheb-GEF independent of its kinase activity to activate mTORC1. Cell Res. 2025 Jul;35(7):497-509.
CoA	CoA of BIEGi-1

Smiles:	O=C1N(C=2C(C=C1CC3=CC=CC=C3)=CN=C(NC4=C(OC)C=C(C=C4)N5CCN(C)CC5)N2)C6=CC(NC(/C=C/C)=O)=CC=C6


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