BI-7446

BI-7446 is a cyclic dinucleotide (CDN)-based potent and selective stimulator of interferon genes (STING) agonist. BI-7446 can activate all five STING variants in cells and induce tumor-specific immune-mediated tumor rejection. BI 7446 can be used for immuno-oncology research.


Cat. No.: EX-A8289	Purity: >98%

	Chemical structure of BI-7446

For research only, Do not use for Human!

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CAS No.	2767011-00-5
Purity	>98%
Formula	C20H22FN9O10P2S2
Mol Weight	693.519

Reference:	[1]. Kuttruff CA, et al. Discovery of BI 7446: A Potent Cyclic Dinucleotide STING Agonist with Broad-Spectrum Variant Activity for the Treatment of Cancer. J Med Chem. 2023 Jul 27;66(14):9376-9400.
CoA	CoA of BI-7446

Smiles:	O[C@H]1[C@@H](O2)[C@H](N3C(C=NNC4=O)=C4N=C3)O[C@@H]1CO[P@](O[C@H]5[C@@H](F)[C@H](N6C(N=CN=C7N)=C7N=C6)O[C@@H]5CO[P@]2(S)=O)(S)=O


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