BI-1015550

BI 1015550 is an orally active inhibitor of PDE4B with an IC50 value of 7.2 nM. BI 1015550 has good safety and potential applications in inflammation, allergic diseases, pulmonary fibrosis, and chronic obstructive pulmonary disease (COPD).


Cat. No.: EX-A7747	Purity: >98%

	Chemical structure of BI-1015550

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
100mg	385	In-stock
250mg	650	In-stock
500mg	900	In-stock
1g	1400	In-stock
5g	4476	In-stock
10g	6928	In-stock

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Synonyms	Nerandomilast
Synonyms 2	BI 1015550
CAS No.	1423719-30-5
Purity	>98%
Formula	C20H25ClN6O2S
Mol Weight	448.97
Color	Off-white to light yellow
State	solid powder
Solubility	DMSO : 6.67 mg/mL
Shelf Life	>3 years if stored properly
Storage	Powder -20°C, 3 years , 4°C, 2 years ; In solvent -20°C, 1 month
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Pouzet P A, et al. Piperidino-dihydrothienopyrimidine sulfoxides and their use for treating COPD and asthma. United States. US9150586. [2]. Herrmann FE, et al. BI 1015550 is a PDE4B Inhibitor and a Clinical Drug Candidate for the Oral Treatment of Idiopathic Pulmonary Fibrosis. Front Pharmacol. 2022 Apr 20;13:838449.
CoA	CoA of BI-1015550

Smiles:	O=[S@]1C2=C(CC1)N=C(N3CCC(CC3)C4=NC=C(C=N4)Cl)N=C2NC5(CO)CCC5


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