BI-0474

BI-0474 is a potent KRAS^G12C inhibitor with an IC₅₀ value of 7.0 nM for the GDP-KRAS::SOS1 protein-protein interaction. BI-0474 exhibits good anti-proliferative activity against NCI-H358 cells carrying the G12C mutation. BI-0474 also shows good anti-tumour activity in non-small cell lung cancer xenograft models.


Cat. No.: EX-A6987	Purity: >98%

	Chemical structure of BI-0474

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
10mg	500	In-stock
25mg	750	In-stock
50mg	1050	In-stock
100mg	1550	In-stock
250mg	2250	In-stock
1g	3900	In-stock

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CAS No.	2750570-55-7
Purity	>98%
Formula	C30H37N9O2S
Mol Weight	587.739
Color	White to off-white
State	solid powder
Solubility	Soluble in DMSO 100 mg/mL
Shelf Life	>3 years if stored properly
Storage	Powder -20℃ 3 years, 4°C 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Bröker J, et al. Fragment Optimization of Reversible Binding to the Switch II Pocket on KRAS Leads to a Potent, In Vivo Active KRASG12C Inhibitor. J Med Chem. 2022 Oct 27.
CoA	CoA of BI-0474


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