BGJ-398

Infigratinib phosphate (BGJ-398 phosphate; NVP-BGJ398 phosphate) is a potent inhibitor of the FGFR family with IC50 of 0.9 nM, 1.4 nM, 1 nM, and 60 nM for FGFR1, FGFR2, FGFR3, and FGFR4, respectively.


Cat. No.: EX-A1550	Purity: >98%

	Chemical structure of BGJ-398

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
1g	500	in_stock
2g	845	in_stock
5g	1471	in_stock
10g	2540	in_stock

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Synonyms	NVP-BGJ398
Synonyms 2	Infigratinib
CAS No.	1310746-10-1
Purity	>98%
Formula	C26H34Cl2N7O7P
Mol Weight	658.471
Color	white to gray
State	solid
Solubility	Soluble in DMSO
Shelf Life	>3 years if stored properly
Storage	Powder 4°C, sealed storage, away from moisture *In solvent : -80°C, 1 year; -20°C, 6 months (sealed storage, away from moisture)
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Guagnano V, et al. Discovery of 3-(2,6-Dichloro-3,5-dimethoxy-phenyl)-1-{6-[4-(4-ethyl-piperazin-1-yl)-phenylamino]-pyrimidin-4-yl}-1-me thyl-urea (NVP-BGJ398), A Potent and Selective Inhibitor of the Fibroblast Growth Factor Receptor Family of Receptor T [2]. Konecny GE, et al. Activity of the fibroblast growth factor receptor inhibitors dovitinib (TKI258) and NVP-BGJ398 in human endometrial cancer cells. Mol Cancer Ther. 2013 May;12(5):632-42.
CoA	CoA of BGJ-398

Smiles:	OP(O)(O)=O.CCN1CCN(CC1)C1=CC=C(NC2=NC=NC(=C2)N(C)C(=O)NC2=C(Cl)C(OC)=CC(OC)=C2Cl)C=C1


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